IFI16 (CT) Antilichaam

IFI16 Antibody: IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer. Increased expression of IFI16 predicts adverse prognosis in multiple myeloma. IFI16 isoforms with cytoplasmic and nuclear locations play differential roles in recognizing invaded DNA viruses. IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nuclear sensor IFI16 inhibits the function of Hepatitis B virus covalently closed circular DNA by integrating innate immune activation and epigenetic suppression.

3428

Q16666

Q16666.3

Human, Mouse, Rat

9641

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Transcription

IFI16 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 - K562 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Gorilla (100%), chimpanzee (100%)

IFI16 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IFI16 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human IFI16 has 4 isoforms, including isoform 1 (785aa, 8.3kD), isoform 2 (729aa, 82.1kD), isoform 3 (673aa, 75.9kD), and isoform 4 (729aa, 82.6kD)

IFI16

Cat. No. 17-06 - Molt4 Cell Slide

Interferon gamma inducible protein 16

Homo sapiens

Ka et al. Cell Rep. 2021; 37 (12) :110138

Huang et al. Pharmacogenomics J. 2021; 21 (4) :520-532

Li et al. J Immunol. 2021; 207 (11) :2699-2709

Jiang et al. Nat Microbiol. 2021; 6 (7) :932-945

Yang et al. Hepatology 2020; 71 (4) :1154-1169

IFI16 Antibody: Gamma-interferon-inducible protein 16, Ifi-16, Interferon-inducible myeloid differentiation transcriptional activator, IFNGIP1

ELISA, WB, IF, IHC

118572657

Liquid