IFIT3 Antilichaam

The interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides (1,2) . These proteins have been suggested to induce anti-viral cellular activities in response to infection (2) . IFIT3 has been shown to interact with TBK1 following RNA virus infection, thereby bridging TBK1 to VISA on the mitochondrion and activating IRF3 and thus the immune response (3) .

3437

O14879

NP_001026853

Human

Unconjugated

Primary Antibodies

Innate Immunity

IFIT3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1211 - HepG2 Cell Lysate

1 mg/mL

IFIT3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IFIT3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

IFIT3 antibody is human specific. This antibody is predicted to not cross-react with other members of the IFIT protein family.

IFIT3

Cat. No. 10-201 - Human Liver Tissue Slide

Interferon-induced protein with tetratricopeptide repeats 3

Homo sapiens

Yu M, Tong JH, Mao M, et al. Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon-stimulating genes. Proc. Natl. Acad. Sci. USA 1997; 94:7406-11.

Fensterl V and Sen GC. The ISG56/IFIT1 gene family. J. Interferon Cytokine Res. 2011; 31:71-8.

Raychoudhuri A, Shrivastava S, Steele R, et al. ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J. Virol. 2011; 85:12881-9.

IFIT3 Antibody : P60, IRG2, IFI60, IFIT4, ISG60, RIG-G, CIG-49, GARG-49, Interferon-induced protein with tetratricopeptide repeats 3, CIG49, IFIT-3

ELISA, WB, IHC-P

72534658

Liquid