IFN-beta-antilichaam

IFN-beta Antibody: Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

3456

P01574

AAC41702

Human, Mouse, Rat

4243

Unconjugated

Primary Antibodies

Independent Antibody Validation in Cell lines (Figure 2) shows similar IFN-beta expression profile in human and mouse cell lines detected by two independent anti-IFN-beta antibodies that recognize different epitopes, 4243 against central domain and 64-239 against human recombinant protein. IFN-beta proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4243 64-239 Recombinant Protein Test (Figure 3) : Anti-IFN-beta antibodies (4243) detected human IFN-beta recombinant protein. Recombinant Protein Test4243

Immunology, Inflammasomes

IFN-beta Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

IFN-beta Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IFN-beta antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human IFN-beta has one (187aa, 22kD) . Mouse IFN-beta has one isoform (182aa, 22kD) and Rat IFN-beta also has one isoform (184aa, 22kD) . 4243 can detect human isoform, and possibly detect mouse and rat.

IFNB1

Cat. No. 1304 - Human Liver Tissue Lysate

Cat. No. 10-201 - Human Liver Tissue Slide

Interferon, beta 1, fibroblast

Homo sapiens

Gresser. J. Leuk. Biol.1997; 61:567-74.

Colonna. Eur. J. Immunol.2007; 37:306-9.

Kock et al. Ann. Neurol.2007; epub.

IFN-beta Antibody: IFB, IFF, IFNB, IFB, Interferon beta, Fibroblast interferon, IFN-beta

ELISA, WB, IHC-P, IF

184623

Liquid