IFN-gamma Antilichaam

IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains

3458

P01579

P01579

Human

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIFN gamma (human Interferon-gamma) .

Unconjugated

Primary Antibodies, Functional Antibodies, Antibody Pairs

Immunology, Chemokines & Cytokines

Anti-hIFN gamma specific antibody was purified by affinity chromatography employing immobilized hIFN gamma matrix.

Batch dependent

None

Room Temp

IFN-gamma antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

IFNG

Interferon, gamma

Homo sapiens

IFG, IFIInterferon gamma, Immune interferon, IFN-gamma

ELISA, WB, Neutralization Assay

124479

Lyophilized