IFNgamma-antilichaam [3F1E3]

Interferon-g (IFN-γ ) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-γ strongly suppresses osteoclastogenesis by interfering with the RANKL (602642) -RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.

3458

P01579

P01579

Human

Ni-NTA purified recombinant human IFN-γ expressed in E. Coli strain BL21 (DE3) .

3F1E3

Unconjugated

Primary Antibodies

Other

Antibody is purified by protein A affinity chromatography.

Batch dependent

Purified antibody in PBS containing 0.03% sodium azide.

None

Blue Ice

IFN-gamma monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

IFNG

Interferon, gamma

Homo sapiens

Takayanagi, H. et al. Nature 2000. 408: 600-605.

Tsubota, K. et al. Invest. Ophthal. Vis. Sci. 40: 28-34, 1999.

Immune interferon, IFN-gamma, IFG, IFI

ELISA, WB

124479