IGF 1R (Ab 1280) Antilichaam

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

3480

P08069

NP_000866.1

Human, Mouse, Rat

IGF-1R (Ab-1280) antibody was raised against a peptide sequence around aa. 1278~1282 (S-F-Y-Y-S) derived from Human IGF-1R .

Unconjugated

Primary Antibodies

Other

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

200, 95 kDa

This antibody detects endogenous level of total IGF-1R protein.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

IGF1R

Insulin-like growth factor 1 receptor

Homo sapiens

Adams, T. E. et al. (2000) Cell. Mol. Life Sci. 57, 1050-1093Baserga, R. et al. (2000) Oncogene 19, 5574-5581Scheidegger, K. J. et al. (2000) J. Biol. Chem. 275, 38921-38928. O'Connor R, et al. Mol Cell Biol 1997 Jan; 17 (1) : 427-35

IGFR, CD221, IGFIR, JTK13, PDGFR, PDGFR1, Insulin-like growth factor I receptor

WB, IHC

4557665

Liquid