IGF1R Antilichaam

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

3480

P08069

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 660-760 of human IGF1R (NP_000866.1) .

Unconjugated

Primary Antibodies

Apoptosis, Cancer, Cell Cycle, Growth Factors, Immunology, Signal Transduction

Affinity purification

293T

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 90kDa/130kDa

IgG

IGF1R

HepG2

A375

HeLa

MCF7

Mouse kidney

Insulin-like growth factor 1 receptor

Homo sapiens

IGF1R, CD221 antigen, CD221, IGF1 Receptor, IGFR, IGF-I receptor, Soluble IGF1R variant 1, Soluble IGF1R variant 2, Type 1 IGF receptor, IGFIR, JTK13

WB, IHC, IF

Liquid