IGF1R Antilichaam [3C8B1]

IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function, including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151) .Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

3480

P08069

P08069

Human

Ni-NTA purified truncated recombinant IGF1R-His expressed in E. Coli strain BL21 (DE3) .

3C8B1

Unconjugated

Primary Antibodies

Growth Factors

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

IGF1R monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG2b

IGF1R

Insulin-like growth factor 1 receptor

Homo sapiens

Adams, T.E. et al. Cell. Mol. Life Sci. 2000 57, 1050-1093.

Baserga, R. et al. Oncogene 2000 19, 5574-5581.

Scheidegger, K.J. et al. J. Biol. Chem. 2000 275, 38921-38928.

Insulin-like growth factor I receptor, IGF-I receptor, IGFR, CD221, IGFIR, JTK13

ELISA, WB, IHC

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