IGF1R (fosfo Tyr1346) Antilichaam

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

3480

P08069

NP_000866.1

Human, Mouse, Rat

IGF1R (phospho Tyr1346) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1346 (Q-P-Y (p) -A-H) derived from Human IGF1R .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

154 kDa

IgG

The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346.

IGF1R

Insulin-like growth factor 1 receptor

Homo sapiens

Ullrich A., EMBO J. 5:2503-2512 (1986) .

Abbot A.M., J. Biol. Chem. 267:10759-10763 (1992) .

The MGC Project Team; Genome Res. 14:2121-2127 (2004) .

CD221, kinase IGF1R, IGF1R

IHC

4557665

Liquid