IGF2R (fosfo Ser2409) Antilichaam

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

3482

P11717

NP_000867.2

Human, Mouse

IGF2R (phospho Ser2409) antibody was raised against a peptide sequence around phosphorylation site of Serine 2409 (Q-D-S (p) -E-D) derived from Human IGF2R.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

300 kDa

IgG

The antibody detects endogenous levels of IGF2R only when phosphorylated at serine 2409.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

IGF2R

Insulin-like growth factor 2 receptor

Homo sapiens

Morgan D.O., Nature 329:301-307 (1987) .

Oshima A., J. Biol. Chem. 263:2553-2562 (1988) .

Killian J.K., Mamm. Genome 10:74-77 (1999)

CI-MPR, CI-MPR, MPR300, MPRI

WB, IHC

317373416

Liquid