IITZ-02

IITZ-02 is a lysosomotropic Autophagy inhibitor. IITZ-02 enhances autophagosome accumulation but inhibits autophagosomal degradation by impairing lysosomal function, finally inducing the inhibition of autophagy. IITZ-02 abolishes mitochondrial membrane potential and induces apoptosis through the mitochondria-mediated pathway. IITZ-02 has a potent antitumor activity in MDA-MB-231 xenograft mouse models. IITZ-02 can be used for cancers research[1].

1807988-46-0

12352005

Apoptosis; Autophagy; Mitochondrial Metabolism

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Cancer

96.51

DMSO : 100 mg/mL (ultrasonic)

COC(C=C1)=CC=C1NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=C(N5)C=CC=C6)C=C4)=N2

C27H26N8O2

494.55

[1]Guntuku L, et al. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo. Oncogene. 2019 Jan;38 (4) :581-595.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-203817/

Reference compound1

No Development Reported