IkB a (fosfotyr42) Antilichaam

Inhibits the activity of dimeric NF-κ -B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

4792

P25963

NP_065390.1

Human, Mouse, Rat

IkB-a (Phospho-Tyr42) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 42 (E-E-Y (p) -E-Q) derived from Human IkappaB-α .

Unconjugated

Primary Antibodies

Phospho-Specific, Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

39 kDa

This antibody detects endogenous levels of IkappaB-α only when phosphorylated at tyrosine 42.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

NFKBIA

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

Homo sapiens

Beraud C, et al. (1999) Proc Natl Acad Sci U S A 96 (2) : 429-434. Sundstrom S, et al. (2005) J Virol 79 (4) : 2230-2239. Liu L, et al. (1998) Mol Cell Biol 18 (7) : 4221-4234. Shrivastava A, et al. (1998) J Virol 72 (12) : 9722-9728.

IKBA, MAD-3, NFKBI, CDC2, CDC28A, CDKN1, P34CDC2, IKBA, NFKBIA

WB, IHC

10092619

Liquid