IkB bèta (fosfo Ser23) Antilichaam

Inhibits NF-κ -B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-κ -B allowing its transport to the nucleus and protecting it to further IKBA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

4793

Q15653

NP_001001716.1

Human, Mouse, Rat

IkB-beta (Phospho-Ser23) antibody was raised against a peptide sequence around phosphorylation site of serine 23 (L-G-S (p) -L-G) derived from Human IkappaB-β .

Unconjugated

Primary Antibodies

Phospho-Specific, Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

48 kDa

This antibody detects endogenous level of IkappaB-β only when phosphorylated at serine 23.

Immunohistochemistry: 1:50~1:100

NFKBIB

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

Homo sapiens

Shirane, M. et al. (1999) J Biol Chem 274, 28169-28174. DiDonato J, et al. (1996) Mol Cell Biol 16 (4) : 1295-304

IKBB, TRIP9, HNF4, NR2A1, TCF14, I-kappa-B-beta, IKB-B, IKBB, NF-kappa-BIB, NF-kappaB inhibitor beta

IHC

48928017

Liquid