IkB epsilon (fosfo Ser22) Antilichaam

Inhibits NF-κ -B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-κ -B p50-p65 and p50-c-Rel complexes.

4794

O00221

NP_004547.2

Human, Mouse

IkB-epsilon (Phospho-Ser22) antibody was raised against a peptide sequence around phosphorylation site of serine 22 (I-E-S (p) -L-R) derived from Human IkB-ε .

Unconjugated

Primary Antibodies

Phospho-Specific, Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

40 kDa

This antibody detects endogenous level of IkappaB-ε only when phosphorylated at serine 22.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

NFKBIE

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Homo sapiens

Shirane M, et al. (1999) J Biol Chem; 274 (40) : 28169-74Karin, M. and Ben-Neriah, Y. (2000) Annu. Rev. Immunol. ;18, 621-663. Chen, Z. J. et al. (1996) Cell; 84, 853-862. Brown, K. et al. (1995) Science; 267, 1485-1488.

IKBE, BHLHE39, I-kappa-B-epsilon, IKBE, IkappaBepsilon, NF-kappa-BIE, NF-kappaB inhibitor epsilon

WB, IHC

71274109

Liquid