IKK-alfa (IKKa) Adenovirus (Ad-CMV-IKKa)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
The transcription factor NFÎoB is retained in the cytoplasm in an inactive form by the inhibitory protein IÎoB. Activation of NFÎoB requires that IÎoB be phosphorylated on specific serines residues, which results in targeted degradation of IÎoB. IÎoB kinase α (IKKα), previously designated CHUK, interacts with IÎoB-α and specifically phosphorylates IÎoB-α on the sites that trigger its degradation, serines 32 and 36. IKKα appears to be critical for NFÎoB activation in response to proinflammatory cytokines. Phosphorylation of IÎoB by IKKα is stimulated by the NFÎoB inducing kinase (NIK), which itself is a central regulator for NFÎoB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKα , IKKÎ2 and IKKÎ3 (also designated NEMO), and each appear to make essential contributions to IÎoB phosphorylation.
IKK-alpha (IKKa) Adenovirus
41106621
3822190000
Pre-Made
Dry Ice
-80C
12 Months
Ad-CMV-IKKa
Human Adenovirus Type5 (dE1/E3)
CMV (ubiquitous)
DMEM, 2% BSA, 2.5% Glycerol
1x10^10 PFU/ml
Beschrijving
The transcription factor NFÎoB is retained in the cytoplasm in an inactive form by the inhibitory protein IÎoB. Activation of NFÎoB requires that IÎoB be ph
Specificaties
Recent bekeken producten
Recombinant TAFV GP1 Protein, C-Fc
EVV03609
100 μg
Gabbr1 Mouse Monoclonal Antibody [Clone ID: S93A-49]
TA326530
100 µg
BSA-Myc/DDK Control Protein
AR100025
50 µL
NH-6
ABC-TC0826
1 Vial
Anti-TAT (Thrombin-antithrombin) Antibody
ABS 014-22-1
1000 µL
Anti-APOE2 mouse monoclonal antibody
TD-AB0132
100 µg
CD35 (CR1) mouse monoclonal antibody, clone J3D3, Azide Free
BM2364
0.2 mg
Anti-KIR2DL1 (Rabbit, Monoclonal, Rabbit mAb)
A115392
100 µL
Recent gezochte producten
Recombinant TAFV GP1 Protein, C-Fc
EVV03609
100 μg
Fluorescein Conjugated Affinity Purified Anti-MOUSE IgG + IgM (H&L) (GOAT) Minimum Cross Reactivity to Bovine, Horse and Human S
GWB-5CB439
1 mg
Horse Polyclonal Horse anti-Goat IgG ImmPRESS(TM) Secondary Antibody [HRP Polymer]
MP-7405-NB-50mL
50 mL
Horse Polyclonal Horse anti-Rabbit IgG ImmPRESS(TM) Secondary Antibody [HRP Polymer]
MP-7401-NB-15mL
15 mL
Horse Polyclonal Horse anti-Mouse IgG ImmPRESS(TM) Secondary Antibody [AP Polymer]
MP-5402-NB-50mL
50 mL
Horse Polyclonal Horse anti-Goat IgG ImmPRESS(TM) Secondary Antibody [HRP Polymer]
MP-7405-NB-15mL
15 mL
Horse Polyclonal Horse anti-Mouse ImmPRESS(TM) VR Secondary Antibody [HRP Polymer]
MP-6402-NB
15 mL
Horse Polyclonal Horse anti-Mouse IgG ImmPRESS(TM) Secondary Antibody [AP Polymer]
MP-5402-NB-15mL
15 mL