IKK-alfa/bèta (fosfo Ser176/177) Antilichaam

Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3.

1147

O15111; O14920

NP_001269.3

Human, Mouse, Rat

IKK- alpha/ beta (phospho Ser176/177) antibody was raised against a peptide sequence around phosphorylation site of serine 176/177 (Q-G-S (p) -L-C) derived from Human IKK-alpha/beta.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

85 kDa

IgG

The antibody detects endogenous level of IKK- alpha/beta only when phosphorylated at serine 176/177.

Western Blot: 1:500~1:1000

CHUK

Conserved helix-loop-helix ubiquitous kinase

Homo sapiens

Chandrakesan P, et al. (2010) J Biol Chem 285, 33485-98

Hinz M, et al. (2010) Mol Cell 40, 63-74

Choudhary S, Lu M, Cui R, Brasier AR (2007) Mol Endocrinol 21, 2203-17

FLJ40509, I-kappa-B kinase, IKBKB, kinase beta, NFKBIKB

WB

62241001

Liquid