IKK alpha Antilichaam

IKK alpha Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and bacteria product LPS. NF-κ B is associated with Iκ B proteins in the cell cytoplasm, which inhibit NF-κ B activity. The long-sought Iκ B kinase (IKK), which phosphorylates Iκ B, and mediates Iκ B degradation and NF-κ B activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ ) . IKKα and IKKβ interact with each other and both are essential for the NF-κ B activation. IKKα specifically phosphorylates Iκ B-alpha. IKKα is expressed in a variety of human tissues.

1147

O15111

AF009225

Human

Unconjugated

Primary Antibodies

Signal Transduction

IKK alpha Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (100%)

IKK alpha Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IKK alpha antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Observed: 87 kDa

IgG

This polyclonal antibody has no cross response to IKKb or IKKy.

CHUK

Cat. No. 1201 - HeLa Cell Lysate

Cat. No. 17-005 - Jurkat Cell Slide

Conserved helix-loop-helix ubiquitous kinase

Homo sapiens

DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive Iκ B kinase that activates the transcription factor NF-κ B. Nature 1997;388:548-54

Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. Identification and characterization of an Iκ B kinase. Cell 1997;90:373-83

Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The Iκ B kinase complex (IKK) contains two kinase subunits, IKKα and IKKα , necessary for Iκ B phosphorylation and NF-κ B activation. Cell 1997;91:243-52

Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DY. Iκ B kinase-β : NF-κ B activation and complex formation with Iκ B kinase-α and NIK. Science 1997;278:866-9

IKK alpha Antibody: IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase alpha

ELISA, WB, ICC

2327068

Liquid