IKK beta Antilichaam

IKK beta Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα , and bacteria product LPS. NF-κ B is associated with Iκ B proteins in the cell cytoplasm, which inhibit NF-κ B activity. The long-sought Iκ B kinase (IKK), which phosphorylates Iκ B, and mediates Iκ B degradation and NF-κ B activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ ) . IKKα and IKKβ interact with each other and both are essential for NF-κ B activation. IKKβ phosphorylates both Iκ B-alpha and Iκ B-beta. IKKβ is expressed in variety of human tissues.

3551

O14920

O14920

Human

Unconjugated

Primary Antibodies

Signal Transduction

IKK beta Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rat: (95%), Mouse: (95%)

IKK beta Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IKK beta antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

87 kDa

IgG

This polyclonal antibody has no cross response to IKKa or IKKy.

IKBKB

Cat. No. 1201 - HeLa Cell Lysate

Cat. No. 17-001 - HeLa Cell Slide

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Homo sapiens

DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive Iκ B kinase that activates the transcription factor NF-κ B. Nature 1997;388:548-54

Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. Identification and characterization of an Iκ B kinase. Cell 1997;90:373-83

Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The Iκ B kinase complex (IKK) contains two kinase subunits, IKKα and IKKα , necessary for Iκ B phosphorylation and NF-κ B activation. Cell 1997;91:243-52

Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DY. Iκ B kinase-β : NF-κ B activation and complex formation with Iκ B kinase-α and NIK. Science 1997;278:866-9

IKK beta Antibody: IKK2, IKKB, IMD15, NFKBIKB, IKK-beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta

ELISA, WB, ICC, IF

14285497

Liquid