IKK-γ (fosfo Ser376) Antilichaam

Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation.

8517

Q9Y6K9

NP_001093327.1

Human

IKK-γ (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Y-L-S (p) -S-P) derived from Human IKK-γ.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

48 kDa

IgG

The antibody detects endogenous levels of IKK-γ only when phosphorylated at serine 376.

IKBKG

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Homo sapiens

Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047 (1999) .

Jin D.-Y., J. Biomed. Sci. 6:115-120 (1999) .

Rothwarf D.M., Nature 395:297-300 (1998) .

FIP3, IKBKG, IKKAP1, IKKG, NF-kappaB

IHC

3641279

Liquid