IKK gamma-antilichaam

IKK gamma Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κ B is associated with Iκ B proteins in the cell cytoplasm, which inhibit NF-κ B activity. The Iκ B kinase (IKKα and IKKβ ) phosphorylates IkB and mediates NF-κ B activation. A novel molecule in the IKK complex was recently identified and termed IKKγ /NEMO/FIP3/IKKAP1. IKKγ interacts with IKKβ and is required for the activation of IKK complex and NF-κ B by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF-κ B activation.

8517

Q9Y6K9

AF074382

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

IKK gamma Antibody is DEAE purified.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/ml

Predicted species reactivity based on immunogen sequence: Bovine: (94%)

IKK gamma Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IKK gamma antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

52 kDa

IgG

IKK gamma has no cross response to IKK alpha or IKK beta.

IKBKG

Cat. No. 17-001 - HeLa Cell Slide

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

Homo sapiens

Rothwarf DM, Zandi E, Natoli G, Karin M. IKK-γ is an essential regulatory subunit of the Iκ B kinase complex. Nature 1998;395 (6699) :297-300

Yamaoka S, Courtois G, Bessia C, Whiteside ST, Weil R, Agou F, Kirk HE, Kay RJ, Israel A. Complementation cloning of NEMO, a component of the Iκ B kinase complex essential for NF-κ B activation. Cell. 1998;93 (7) :1231-40.

Li Y, Kang J, Friedman J, Tarassishin L, Ye J, Kovalenko A, Wallach D, Horwitz MS. Identification of a cell protein (FIP-3) as a modulator of NF-κ B activity and as a target of an adenovirus inhibitor of tumor necrosis factor α -induced apoptosis. Proc Natl Acad Sci U S A 1999;96 (3) :1042-7

Mercurio F, Murray BW, Shevchenko A, Bennett BL, Young DB, Li JW, Pascual G, Motiwala A, Zhu H, Mann M, Manning AM. Iκ B kinase (IKK) -associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol. 1999;19 (2) :1526-38.

IKK gamma Antibody: IP, IP1, IP2, FIP3, IPD2, NEMO, FIP-3, Fip3p, AMCBX1, ZC2HC9, IKK-gamma, NF-kappa-B essential modulator

ELISA, WB, ICC, IF

3641279

Liquid