IL-10 Antilichaam [3C12C12]

Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down- regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

3586

P22301

P22301

Human

Ni-NTA purified recombinant human IL-10 expressed in E. Coli strain BL21 (DE3) .

3C12C12

Unconjugated

Primary Antibodies

Immunology, Innate Immunity

Antibody is purified by protein A affinity chromatography.

Batch dependent

Purified antibody in PBS containing 0.03% sodium azide.

None

Blue Ice

To IL-10 monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1.kappa

IL10

Interleukin 10

Homo sapiens

Vieira P, et al. PNAS, 1991.88:1172-1176.

Cytokine synthesis inhibitory factor, IL-10, CSIF, TGIF, GVHDS, IL10A

ELISA, WB

124292