IL-10 Antilichaam (biotine)

Interleukins (ILs) are a large group of cytokines that are produced mainly by leukocytes, although some are produced by certain phagocytes and auxiliary cells. ILs have a variety of functions, but most function to direct other immune cells to divide and differentiate. Each IL acts on a specific, limited group of cells through a receptor specific for that IL. Human IL10 is a non glycosylated polypeptide consisting of 178 amino acids. There is 73% homology between the human and mouse IL10 proteins, however, the human IL10 acts on both human and mouse target cells, while the mouse IL10 has species specific activity. The cellular sources of IL10 are CD4+ T cells and T cell clones, thymocytes, B cells and B cell lymphomas, macrophages, mast cell lines and keratinocytes. IL10 will stimulate the growth of stem cells, mast cells and thymocytes. IL10 enhances cytotoxic T cell development, and costimulates B cell differentiation and immunoglobulin secretion. IL10 inhibits cytokine production by macrophages and suppresses macrophage class II MHC expression. The human IL10 gene is on human chromosome

3586

P22301

P22301

Human

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIL-10 (human IL-10) .

Biotin

Primary Antibodies, Antibody Pairs

Immunology, Chemokines & Cytokines

Anti-hIL-10 specific antibody was purified by affinity chromatography and then biotinylated.

Batch dependent

None

Room Temp

IL-10 antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

IL10

Interleukin 10

Homo sapiens

CSIF, TGIF, GVHDS, IL-10, IL10AInterleukin-10, Cytokine synthesis inhibitory factor

ELISA, WB

124292

Lyophilized