IL-11 Antilichaam

Interleukin 11 is a pleiotropic cytokine that has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6 (1) . It directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (2) . IL-11 promotes the proliferation of hepatocytes in response to liver damage. IL-11 binds to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 (3) . Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelo-suppressive chemotherapy (4) .

3589

P20809

NP_000632

Human

Unconjugated

Primary Antibodies

Stem Cell, Immunology

IL-11 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (88%)

IL-11 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-11 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist; this antibody will only detect the longest isoform of IL-11.

IL-11

Cat. No. 17-001 - HeLa Cell Slide

Interleukin 11

Homo sapiens

Paul SR, Bennett F, Calvetti JA. Molecular cloning of a cDNA encoding interleukin-11, astromal cell-derived lymphopoietic and hematopoietic cytokine. Proc. Natl. Acad. Sci. USA 1990; 87:7512-6.

Yang YC and Yin T. Interleukin (IL) -11 mediated signal transduction. Ann. N.Y. Acad. Sci. 1995; 762:31-40.

Dimitriadis E, Robb L, Salamonsen LA. Interleukin 11 advances progesterone-induced decidualization of human endometrial stromal cells. Mol. Hum. Reprod. 2002; 8:636-43.

Andersson By U, Tani E, Andersson U. Tumor necrosis factor, interleukin 11, and leukemia inhibitory factor produced by Langerhans cells in Langerhans cell histiocytosis. J. Pediatr. Hematol. Oncol. 2004; 26:706-11.

Interleukin-11, Adipogenesis inhibitory factor, AGIF

ELISA, WB, ICC, IF

10834994

Liquid