IL-12 Recombinant eiwit

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

3593

P29460

NP_002178.2

Recombinant Proteins

(BTI-Tn-5B1-4) High-5 Insect cells

Cancer, Immunology, Infectious Disease, Innate Immunity, Signal Transduction

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Room Temp

The lyophilized IL-12 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IL-12 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IL-12 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

Homo sapiens

CLMF, NKSF, CLMF2, NKSF2, IL-12B, Interleukin-12 subunit beta, Cytotoxic lymphocyte maturation factor 40 kDa subunit

Human

24497438

Lyophilized