IL-15 Antilichaam

IL-15 Antibody: Interleukin 15 (IL-15) is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis.

3600

P40933

NP_000576

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

IL-15 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1466 - Rat Spleen Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Guinea pig: (100%), Sheep: (92%), Rabbit: (92%), Pig: (92%), Bovine: (92%)

IL-15 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-15 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

18 kDa

IgG

At least two isoforms of IL-15 are known to exist.

IL15

Interleukin 15

Homo sapiens

Bodnar A, Nizsaloczki E, Mocsar G, et al. A biophysical approach to IL-2 and IL-15 receptor function: localization, conformation and interactions. Immunol. Lett. 2008; 116:117-25.

Ku CC, Murakami M, Sakamoto A, et al. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 2000; 288:675-8.

Waldmann T, Tagaya Y, and Bamford R. Interleukin-2, interleukin-15, and their receptors. Int. Rev. Immunol. 1998; 16:205-26.

Masuda A, Matsuguchi T, Yamaki K, et al. Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediate Bcl-xL expression. J. Biol. Chem. 2001; 276:26107-13.

IL-15 Antibody: IL-15, Interleukin-15, IL-15

ELISA, WB, IHC-P

10835153

Liquid