IL-17 Antilichaam

IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κ B and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

3605

Q16552

NP_002181

Human, Mouse

Unconjugated

Primary Antibodies

Recombinant Protein Test (Figure 3) : Anit-IL-17 antibodies (4877) detected human IL-17 recombinant protein at different concentrations. Recombinant Protein Test4877

Signal Transduction

IL-17 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1208 - THP-1 Cell Lysate

1 mg/mL

IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human IL-17 has only one isoform (155aa, 17.5kD) . Mouse IL-17 has one isoform (158aa, 17.5kD) and rat IL-17 also has one isoform (150aa, 16.9kD) . 4877 can detect only human isoform, but cannot detect mouse and rat.

IL17A

Cat. No. 1288 - A20 Cell Lysate

Interleukin 17A

Homo sapiens

Miossec. Curr. Opin. Rheumatol.2000; 12:181-5.

Paunovic et al. Rheumatol.2008; 47:771-6.

Steinman. Nat. Med.2007; 13:139-145.

IL-17 Antibody: IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8

ELISA, WB

4504651

Liquid