IL-17 Antilichaam

IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κ B and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

3605

Q16552

NP_002181

Human, Mouse

4887

Unconjugated

Primary Antibodies

Recombinant Protein Test (Figure 1) : Anit-IL-17 antibodies (4887) detected human IL-17 recombinant protein at different concentrations Recombinant Protein Test4887

Signal Transduction

IL-17 Antibody is affinity chromatography purified via peptide column.

Cat. No. 17-208 - A20 Cell Slide

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (84%), Rat: (81%), Pig: (74%)

IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-17 antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human IL-17 has only one isoform (155aa, 17.5kD) . Mouse IL-17 has one isoform (158aa, 17.5kD) and Rat IL-17 also has one isoform (150aa, 16.9kD) . 4887 can detect human, mouse and rat IL-17.

IL17A

Interleukin 17A

Homo sapiens

Miossec. Curr. Opin. Rheumatol.2000; 12:181-5.

Paunovic et al. Rheumatol.2008; 47:771-6.

Steinman. Nat. Med.2007; 13:139-145.

IL-17 Antibody: IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8

ELISA, WB, IHC-P, IF

4504651

Liquid