IL-17RA Antilichaam

IL-17RA Antibody: Interleukin 17A (IL-17A) is a proinflammatory cytokine secreted by activated T-lymphocytes (1) . It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17RA is a ubiquitous type I membrane glycoprotein that binds with low affinity to IL-17A and IL-17F (1,2) . IL-17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis (3,4) . Defects in IL-17RA are the cause of familial candidiasis type 5 (CANDF5) which is a rare disorder with altered immune responses and impaired clearance of fungal infections (5) .

23765

Q96F46

NP_055154

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

IL-17RA Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

IL-17RA Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-17RA antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Other IL-17RA antibodies show similar size band

IgG

IL-17RA antibody is human, mouse and rat reactive. Multiple isoforms of IL-17RA are known to exist. This antibody is predicted to not cross-react with other IL-17 receptor subunits.

IL17RA

Cat. No. 10-901 - Human Spleen Tissue Slide

Interleukin 17 receptor A

Homo sapiens

Yao Z, Painter SL, Fanslow WC, et al. Human IL-17: a novel cytokine derived from T cells. J. Immunol. 1995; 155: 5483-6.

Yao Z, Fanslow WC, Seldin MF, et al. Herpesvirus saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 1995; 3:811-21.

Rickel EA, Siegel LA, Yoon BR, et al. Identification of functional roles for both IL-17RB and IL-17RA in mediating IL-25-induced activities. J. Immunol. 2008;181:4299-310.

Wang M, Wang L, Ren T, et al. IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells. Cancer Biol. Ther. 2012;14 (2) .

IL-17RA Antibody: CD217, IL17R, CANDF5, CDw217, IL-17RA, hIL-17R, Interleukin-17 receptor A, IL-17 receptor A

ELISA, WB, IHC-P, IF

23238208

Liquid