IL-17RE Antilichaam

IL-17RE Antibody: The interleukin 17 receptor E (IL-17RE) shares limited similarity to the receptor of IL-17A, a ubiquitous type I membrane glycoprotein that with IL-17A plays a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL-17RE is the functional receptor of IL-17C and has been suggested to mediate mucosal immunity to infection with intestinal pathogens. IL-17C is produced by epithelia in response to bacterial challenge and binds to a receptor complex formed by IL-17RE and IL-17RA on the epithelial cell surface, thereby regulating the immune function of epithelial cells in an autocrine manner.

132014

Q8NFR9

NP_705616

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

IL-17RE Antibody is affinity chromatography purified via peptide column.

Cat. No. 1316 - Human Ovary Tissue Lysate

1 mg/mL

IL-17RE Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-17RE antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Predicted: 78 kDa

IgG

IL17RE

Interleukin 17 receptor E

Homo sapiens

Li TS, Li XN, Chang CJ, et al. Identification and functional characterization of a novel interleukin 17 receptor: a possible mitogenic activation through ras/mitogen-activated protein kinase signaling pathway. Cell Signal. 2006; 18:1287-98.

Moseley TA, Haudenschild DR, Rose L, et al. Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 2003; 14:155-74.

Song Z, Zhu S, Shi P, et al. IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens. Nat. Immunol. 2011; 12:1151-8.

Ramirez-Carrozzi V, Sambandam A, Luis E, et al. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol. 2011; 12:1159-66

IL-17RE Antibody: Interleukin-17 receptor E, IL-17 receptor E

ELISA, WB

301129232

Liquid