IL-1RAcP Antilichaam

IL-1RAcP Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP) . IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-κ B inducing kinae (NIK) and of NF-κ B, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.

3556

Q9NPH3

NP_002173

Human

Unconjugated

Primary Antibodies

Chemokines & Cytokines

IL-1RAcP Antibody is affinity chromatography purified via peptide column.

Cat. No. 1204 – K562 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (91%), Mouse: (86%)

IL-1RAcP Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-1RAcP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

It has no cross activity to other member in the IL-1 receptor family.

IL1RAP

Cat. No. 17-001 - HeLa Cell Slide

Interleukin 1 receptor accessory protein

Homo sapiens

Greenfeder SA, Nunes P, Kwee L, et al. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J. Biol. Chem. 1995;270:13757-65.

Huang J, Gao X, Li S, et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 1997; 94:12829-32.

Wesche H, Korherr C, Kracht M, et al. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases) . J. Biol. Chem. 1997;272:7727-31.

Hofmeister R, Wiegmann K, Korherr C, et al. Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein. J. Biol. Chem. 1997; 272:27730-6.

IL-1RAcP Antibody: IL1R3, C3orf13, IL-1RAcP, IL1R3, Interleukin-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1 receptor accessory protein

ELISA, WB, ICC

2599126

Liquid