IL-21 Receptor Antilichaam

IL-21 Receptor Antibody: A novel cytokine related to IL2 and IL15 was recently identified and designated IL-21. The receptor for IL-21 (IL-21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling. Both IL-21R and the gc are necessary for the IL-21 function. IL-21 and its receptor activate JAK-STAT signaling pathway. IL-21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL-21 plays a role in the proliferation and maturation of NK, B and T cell populations.

50615

Q9HBE5

NP_068570

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Chemokines & Cytokines

IL-21 Receptor Antibody is affinity chromatography purified via peptide column.

Cat. No. 1207 - Raji Cell Lysate

1 mg/ml

IL-21 Receptor Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-21 Receptor antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

60 kDa

IgG

IL21R

Interleukin 21 receptor

Homo sapiens

Parrish-Novak J, Dillon SR, Nelson A, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature. 2000;408 (6808) :57-63.

Ozaki K, Kikly K, Michalovich D, et al. Cloning of a type I cytokine receptor most related to the IL-2 receptor β chain. Proc Natl Acad Sci USA. 2000;97 (21) :11439-44.

Asao H, Okuyama C, Kumaki S, et al. the common γ -chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167 (1) :1-5.

Vosshenrich CA, Di Santo JP. Cytokines: IL-21 joins the γ (c) -dependent network Curr Biol. 2001;11 (5) :R175-7.

IL-21 Receptor Antibody: NILR, CD360, NILR, UNQ3121/PRO10273, Interleukin-21 receptor, Novel interleukin receptor, IL-21 receptor

ELISA, WB, IF

11141869

Liquid