IL-22 Antilichaam

Interleukin-22 (IL-22) is a cytokine important for the modulation of tissue responses during inflammation (1) . Unlike the distantly related IL-10, IL-22 does not inhibit the production of proinflammatory cytokines in monocytes in response to LPS, but it has some inhibitory effects on IL-4 production from Th2 T cells. IL-22 is expressed by both the adaptive arm of the immune system such as CD4 T cell subsets including Th17 cells, as well as by innate lymphocytes such as NK and LTi-like cells (2) . IL-22 is highly expressed in several chronic inflammatory conditions, and studies suggest that IL-22 plays both inflammatory and protective roles (3) .

50616

Q9GZX6

NP_065386

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

IL-22 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

IL-22 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-22 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

IL-22 antibody is human, mouse, and rat reactive. Multiple isoforms of IL-22 are known to exist.

IL22

Cat. No. 17-001 - HeLa Cell Slide

Interleukin 22

Homo sapiens

Xie MH, Aggarwal S, Ho WH, et al. Interleukin (IL) -22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J. Biol. Chem. 2000; 275:31335-9.

Wolk K, Kunz S, Witte E, et al. IL-22 increases the innate immunity of tissues. Immunity 2004; 21:241-54.

Wolk K, Witte E, Wallace E, et al. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol. 36:1309-23.

IL-22 Antibody: TIFa, IL-21, IL-22, ILTIF, IL-TIF, IL-D110, zcyto18, TIFIL-23, ZCYTO18, UNQ3099/PRO10096, Interleukin-22, Cytokine Zcyto18

ELISA, WB, ICC, IF

10092625

Liquid