IL-23 Antilichaam

IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

51561

Q9NPF7

AAH66268

Human

3793

Unconjugated

Primary Antibodies

Recombinant Protein Test (Figure 3) : Anit-IL-23 antibodies (3793) detected human IL-23 recombinant protein. Recombinant Protein Test3793 Regulated expression validation (Figure 8) : IL-23 expression detected by anit-IL-23 antibodies (3793) was abundant in human abdominal aortic aneurysm (AAA) tissues whereas there is no IL-23 expression in normal tissue. Regulated expression validation3793

Immunology, Chemokines & Cytokines

IL-23 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1207 - Raji Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Guinea pig: (93%), Horse: (93%), Mouse: (71%), Rat: (71%)

IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-23 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human IL-23 has one isoform (189aa, 20.7kD) . Mouse IL-23 has one isoform (196aa, 22.1kD) and Rat IL-23 also has one isoform (196aa, 22kD) . 3793 can detect human IL-23.

IL23A

Cat. No. 11-101 - Human Pancreas Tissue Slide

Cat. No. 17-007 - Raji Cell Slide

Interleukin 23, alpha subunit p19

Homo sapiens

Hunter. Nat. Rev. Immunol. 2005; 5:521-31.

Oppmann et al. Immunity 2000; 13:715-25.

Sheibanie et al. FASEB J. 2004; 18:1318-20.

Pirhonen et al. J. Immunol. 2002; 169:5673-8.

31320700

IL-23 Antibody: P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha

ELISA, WB, IHC-P, ICC, IF

42542809

Liquid