IL-23 Antilichaam

IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

51561

Q9NPF7

AAH66268

Human, Mouse

3795

Unconjugated

Primary Antibodies

Recombinant Protein Test (Figure 2) : Anti-IL-23 antibodies (3795) detected human IL-23 recombinant protein at different concentrations. Recombinant Protein Test3795 Induced Expression Validation (Figure 6) : IL-23 expression detected by anit-AIF antibodies was up-regulated by tape stripping. Induced Expression Validation

Immunology, Chemokines & Cytokines, Neuroscience

IL-23 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1414 - Mouse Pancreas Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Horse: (94%), Pig: (82%), Rat: (76%), Guinea pig: (76%)

IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-23 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

Human IL-23 has one isoform (189aa, 20.7kD) . Mouse IL-23 has one isoform (196aa, 22.1kD) and Rat IL-23 also has one isoform (196aa, 22kD) . 3795 can detect human and mouse, and possibly detect rat.

IL23A

Interleukin 23, alpha subunit p19

Homo sapiens

Hunter. Nat. Rev. Immunol. 2005; 5:521-31.

Oppmann et al. Immunity 2000; 13:715-25.

Sheibanie et al. FASEB J. 2004; 18:1318-20.

Pirhonen et al. J. Immunol. 2002; 169:5673-8.

27551155

IL-23 Antibody: P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha

ELISA, WB, IHC-P, IF

42542809

Liquid