IL-29 / Interleukin-29 Proteïne (Zijn label)

Interleukin-29 (IL-29), also known as cytokine Zcyto21, Interferon lambda-1, IFN-lambda-1, and IFNL1, is a secreted protein that belongs to the IL-28 / IL-29 family. IL-29 is a cytokine with immunomodulatory activity. IL-29 is highly similar in amino acid sequence to the IL-28. IL-28 and IL-29 are induced by a viral infection and showed antiviral activity. IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL-29 may play a role in antiviral immunity. IL-29 up-regulates MHC class I antigen expression. It is a Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.

IL-29 Protein; IL29 Protein; ZCYTO21 Protein

NP_742152.1

Human

Human

His-Tag

See Datasheet send with the product

< 1.0 EU per μg protein as determined by the LAL method.

> 92 % as determined by SDS-PAGE

Measured in antiviral assays using HepG2 cells infected with vesicular stomatitisvirus (VSV) . The ED50 for this effect is typically 4-20 ng/mL.

192

Lyophilized

PBS, pH 7.4

See Datasheet

35 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells