IL-2R alfa/CD25, Canine (HEK293, His)

IL-2R alpha (CD25) is an essential component of high-affinity IL-2 receptors. IL-2R alpha enhances binding of IL-2 to its receptor complex so that regulates T cell growth and other lymphoid functions[1][2]. IL-2R alpha/CD25 Protein, Canine (HEK293, His) is a recombinant canine IL-2R alpha protein with a His tag at the C-terminus and is expressed in HEK293 cells. It consists of 216 amino acids (D22-Q237) .

IL-2R alpha/CD25 Protein, Canine (HEK293, His), Canine, HEK293

12352202

403870 (Gene_ID) O62802 (D22-Q237) (Accession)

45-55 kDa

[1]H.Asao. Interleukin-2. Reference Module in Biomedical Sciences. 2014. ISBN 9780128012383.|[2]Kim HP, et al. The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements. Immunity. 2001 Jul;15 (1) :159-72.|[3]Bell CJ, et al. Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells. J Autoimmun. 2015 Jan;56:66-80.|[4]Chistiakov DA, et al. The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies. Immunol Lett. 2008 Jun 15;118 (1) :1-5.

Room temperature in continental US; may vary elsewhere.

Recombinant Proteins