IL-31 Antilichaam / Interleukin 31

Interleukin 31 (IL-31) is a cytokine that plays a critical role in inflammatory responses and allergic reactions in the body. IL-31 is produced by T-helper 2 (Th2) cells, which are involved in the body's response to allergens and parasites. When released, IL-31 binds to receptors on various cells in the body, triggering a cascade of inflammatory responses that can lead to symptoms such as itching, redness, and swelling. Studies have shown that IL-31 is particularly important in the development of atopic dermatitis, a common skin condition characterized by itchy, inflamed skin. In individuals with atopic dermatitis, levels of IL-31 are often elevated in the skin, leading to increased inflammation and itching. Additionally, IL-31 has also been implicated in other inflammatory conditions such as asthma and inflammatory bowel disease, highlighting its importance in the body's immune response.

Western blot: 1:500-1:1000, Immunohistochemistry (FFPE) : 1:50-1:100, Flow cytometry: 1:10-1:50 per million cells in 0.1ml

Q6EBC2

Human

A portion of amino acids 13-40 from the human protein was used as the immunogen for the IL-31 antibody.

WB, IHC-P, FACS

Antigen affinity

Purified

This IL-31 antibody is available for research use only.

Aliquot the IL-31 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

The stated application concentrations are suggested starting points. Titration of the IL-31 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Secreted

IHC staining of FFPE human testis tissue with IL-31 antibody. HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.