IL-31 Antilichaam [SB118b]

Interleukin-31 (IL-31) is a 24 kDa alpha-helical protein and a member of the IL-6 family of cytokines that is preferentially expressed by CD4+ T cells. This cytokine elicits its response by binding to a heterodimeric complex consisting of a gp130-like receptor chain and the oncostatin M receptor subunit. On target cells which include a broad range of immune and non-immune cells, IL-31 binding can induce activation of the Jak/STAT, AKT, and MAPK signaling pathways. Due to the ubiquitous expression of its receptor complex, IL-31 has numerous physiological roles that include regulating hematopoiesis and immune response. Over-expression has been linked to chronic inflammatory states such as dermatitis, pruritus, airway hypersensitivity, and inflammatory bowel disease.

386653

Q6EBC2

Q6EBC2

Human

E. coli-expressed human IL-31

[SB118b]

Unconjugated

Primary Antibodies

Immunology, Chemokines & Cytokines

1.0 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2b

IL-31

IL-31 Antibody [SB118b] for use in ELISA assays.

IL31

Interleukin 31

Homo sapiens

Interleukin-31

Flow, FLISA

Liquid