IL-32 Antilichaam

IL-32 Antibody: Interleukin-32 (IL-32) was initially identified as a transcript (NK4) that is selectively expressed in lymphocytes and NK cells and whose expression is increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and re-named IL-32. IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. Because treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-α , IL-8 and MIP-2, and because it is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFNγ , it has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.

9235

P24001

AAH09401

Human

3751

Unconjugated

Primary Antibodies

Recombinant Protein Test (Figure 1) : Anti-IL-32 antibodies (3751) detected human IL-32 recombinant protein at different concentrations. Recombinant Protein Test3751

Signal Transduction, Cancer

IL-32 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1205 - Jurkat Cell Lysate

1 mg/mL

IL-32 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-32 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

This antibody detects the largest isoform of IL-32.

Human IL-32 has 7 isoforms, including isoform 1 (234aa, 27kD), isoform 2 (188aa, 22kD), isoform 3 (178aa, 21kD), isoform 4 (131aa, 15kD), isoform 5 (168aa, 19kD), isoform 6 (179aa, 21kD) and isoform 7 (148aa, 17kD) . 3751 can detect all human isoforms except isoforms 5 and 7.

IL32

Interleukin 32

Homo sapiens

Dahl et al. J. Immunol. 1992; 148:597-603.

Kim et al. Immunity 2005; 22:131-42.

Cagnard et al. Eur. Cyto. Network 2005; 16:289-92.

IL-32 Antibody: NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, IL-32beta, IL-32alpha, IL-32delta, IL-32gamma, NK4, Interleukin-32, Natural killer cells protein 4, IL-32

ELISA, WB

14424787

Liquid