IL-33 Antilichaam [SB127j]

Interleukin-33 (IL-33), also known as NF-HEV, is a 30 kDa protein and a member of the IL-1 family. This pro-inflammatory cytokine is produced by a variety of cells but is primarily expressed by endothelial and smooth muscle cells in the vasculature and airways. IL-33 binds to the ST2 receptor on target cells which results in the activation of multiple signaling pathways including NF-κB and MAP kinases. Studies have shown that IL-33 promotes T helper type 2 (Th2) cell-mediated immune responses and upregulates production of Th2 associated cytokines including IL-4, IL-5, and IL-13. In vivo administration of this cytokine in mice results in eosinophilia and splenomegaly as well as induced severe pathological changes in the lungs, gastrointestinal tract, and other mucosal organs.

90865

O95760

O95760

Human

E. coli-expressed human IL-33

[SB127j]

Unconjugated

Primary Antibodies

Innate Immunity

0.5 mg/mL

Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

None

Blue Ice

Store vial at 2-8˚ C

IgG2a

IL-33

IL-33 Antibody [SB127j] for use in ELISA assays.

IL33

Interleukin 33

Homo sapiens

Interleukin-33, IL-1F11, NF-HEV

ELISA, WB, IHC-P, IHC-Fr, ICC, EM

Liquid