IL-36 beta (IL-1F8)

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9) . IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.

FIL1; FIL1H; IL1F8; IL1H2; IL-1F8; IL-1H2; IL1-ETA; FIL1- (ETA) ; FILI- (ETA)

27177

Q9NZH7

NP_055253.2

NM_014438

2q14

Human

Human

MREAAPKSYA IRDSRQMVWV LSGNSLIAAP LSRSIKPVTL HLIACRDTEF SDKEKGNMVY LGIKGKDLCL FCAEIQGKPT LQLKEKNIMD LYVEKKAQKP FLFFHNKEGS TSVFQSVSYP GWFIATSTTS GQPIFLTKER GITNNTNFYL DSVE

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Measured by its ability to induce IL-8 production by human PBMCs.

154

Lyophilized

17.3 kDa

E. coli