IL-36beta Recombinant eiwit

The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36α (IL-1F6), β (IL-1F8) and γ (IL-1F9) . IL-36β is highly expressed in psoriatic plaques, and at lower levels in various other tissues. IL-36β signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36β also functions as an agonist of NF-kappaB, and stimulates the production of pro-inflammatory proteins, including IL-6, IL-8, BD-2, and BD-3. Recombinant human IL-36β is a 17.3 kDa protein containing 154 amino acid residues.

27177

Q9NZH7

NP_055253.2

Recombinant Proteins

E. coli

Immunology

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Room Temp

The lyophilized IL-36beta recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IL-36beta is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IL-36beta recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Interleukin 36, beta

Homo sapiens

FIL1, FIL1H, IL1F8, IL1H2, IL-1F8, IL-1H2, IL1-ETA, FIL1- (ETA), FILI- (ETA), Interleukin-36 beta, FIL1 eta, IL-1 eta

Human

20070252

Lyophilized