IL-36G Antilichaam

IL-36G is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1) . IL-36G is thought to activate the NF-kappaB pathway through IL-1 receptor family members IL-1RL2 and IL-1RAcP (2) . Like the related proteins IL-36A and IL-36B, IL-36G requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (3) . IL-36G expression is stimulated by interferon-gamma, tumor necrosis factor-alpha and interleukin 1 (4) . The IL-36 cytokines have been suggested to amplify Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells (5) .

56300

Q9NZH8

NP_062564

Human

Unconjugated

Primary Antibodies

Immunology

IL-36G antibody is affinity chromatography purified via peptide column.

Cat. No. 1306 - Human Spleen Tissue Lysate

1 mg/mL

IL-36G antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-36G antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

IL-36G antibody is human specific. IL-36G antibody will not cross-react with IL-36A or IL-36B.

IL36G

Interleukin 36, gamma

Homo sapiens

Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75.

Towne JE, Garka KE, Renshaw BR, et al. Interleukin (IL) -1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J. Biol. Chem. 2004; 279:13677-88.

Towne JE, Renshaw BR, Douangpanya J, et al. Interleukin-36 (IL-36) ligands require processing for full agonist agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. J. Biol. Chem. 2011; 286:42594-602.

Chustz RT, Nagarkar DR, Popowski JA, et al. Regulation and function of the IL-1 family cytokine IL-1F9 in human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 2011; 45:145-53.

IL-36G Antibody: IL1E, IL1F9, IL1H1, IL-1F9, IL-1H1, IL1RP2, IL-1RP2, IL1E, UNQ2456/PRO5737, Interleukin-36 gamma, IL-1-related protein 2

ELISA, WB, IHC-P, IF

9665234

Liquid