IL-36RN Antilichaam

IL-36RN is is a member of the interleukin 1 cytokine family whose gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2 (1) . IL-36RN specifically inhibits the activation of NF-kappaB induced IL-36A (2) . The opposing activities of these cytokines have been suggested to be involved in the regulation of skin inflammation (3) . Like the IL-36 cytokines (IL-36A, IL-36B and IL-36G), IL-36RN requires post-translational processing for full agonist activity, but the cleavage mechanism is currently unknown (4) .

26525

Q9UBH0

NP_775262

Human, Mouse

Unconjugated

Primary Antibodies

Immunology

IL-36RN antibody is affinity chromatography purified via peptide column.

Cat. No. 1306 - Human Spleen Tissue Lysate

1 mg/mL

IL-36RN antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-36RN antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Observed Molecular Weight: 24 kDa

IgG

IL-36RN antibody is human and mouse reactive. At least two isoforms of IL-36RN are known to exist

IL36RN

Interleukin 36 receptor antagonist

Homo sapiens

Smith DE, Renshaw BR, Ketchem RR, et al. Four new members expand the interleukin-1 superfamily. J. Biol. Chem. 2000; 275:1169-75.

Debets R, Timans JC, Homey B, et al. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J. Immunol. 2001; 167:1440-6.

Blumberg H, Dinh H, Trueblood ES, et al. Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation. J. Exp. Med. 2007; 204:2603-14.

Towne JE, Renshaw BR, Douangpanya J, et al. Interleukin-36 (IL-36) ligands require processing for full agonist agonist (IL-36a, IL-36b, and IL-36g) or antagonist (IL-36Ra) activity. J. Biol. Chem. 2011; 286:42594-602.

IL-36RN Antibody: FIL1, FIL1D, IL1F5, IL1L1, PSORP, IL1HY1, IL1RP3, IL36RA, FIL1 (DELTA), UNQ1896/PRO4342, Interleukin-36 receptor antagonist protein, FIL1 delta, IL-1RP3

ELISA, WB, IHC-P, IF

27894310

Liquid