IL-37 Antilichaam

Interleukin 37 (IL-37) is a member of the interleukin 1 cytokine family (reviewed in 1) . It can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp) . IL-37 also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18 (1) . IL-37 can also interact with Smad3 and expression of IL-37 in macrophages or epithelial cells resulted in near complete suppression of pro-inflammatory cytokines, suggesting that IL-37 may act as a natural suppressor of the innate inflammatory and immune responses (2,3) .

27178

Q9NZH6

NP_055254

Human

Unconjugated

Primary Antibodies

Immunology

IL-37 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1302 - Human Lung Tissue Lysate

1 mg/mL

IL-37 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

IL-37 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

IL-37 antibody is human specific. Multiple isoforms of IL-37 are known to exist; this antibody will only detect the largest isoform. IL-37 antibody is predicted to not cross-react with IL-36.

IL37

Cat. No. 10-401 - Human Kidney Tissue Slide

Interleukin 37

Homo sapiens

Boraschi D, Lucchesi D, Hainzl S, et al. IL-37: a new anti-inflammatory cytokine of the IL-1 family. Eur. Cytokine Netw. 2011; 22:127-47.

Nold MF, Nold-Petry CA, Zepp JA, et al. Interleukin 37 is a fundamental inhibitor of innate immunity. Nat. Immunol. 2010; 11:1014-22.

Sakai N, Van Sweringen HL, Belizaire RM, et al. Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J. Gastroenterol. Hepatol. 2012; 27:1609-16.

IL-37 Antibody : FIL1, FIL1Z, IL-1H, IL-37, IL1F7, IL1H4, IL-1F7, IL-1H4, IL1RP1, IL-1RP1, FIL1 (ZETA), Interleukin-37, FIL1 zeta

ELISA, WB, IHC-P, IF

20127524

Liquid