IL-4 Antilichaam [1,3 4F11-2G3]

IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

3565

P05112

P05112

Human

The monoclonal antibody was produced in BALB/c x ICR F1 mice using recombinant hIL-4 as the immunizing antigen.

1.3_4F11-2G3

Unconjugated

Primary Antibodies, Functional Antibodies

Immunology, Chemokines & Cytokines

This IgG1k antibody was purified on a Protein A affinity column.

Batch dependent

None

Room Temp

IL-4 lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20˚ C. Reconstitute in sterile water to a concentration of 0.1 - 1.0 mg/mL. The antibody is stable for at least six weeks at 2-4˚ C when reconstituted.

IL4

Interleukin 4

Homo sapiens

Interleukin 4Interleukin-4, B-cell stimulatory factor 1, IL-4, BSF1, BCGF1, BSF-1, BCGF-1

ELISA, WB, Neutralization Assay

124337

Lyophilized