IL-4 Antilichaam

IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

287287

P20096

P20096

Rat

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant Rat IL-4 (Rat Interleukin-4) .

Unconjugated

Primary Antibodies, Antibody Pairs

Immunology, Chemokines & Cytokines

Anti-Rat IL-4 specific antibody was purified by affinity chromatography employing immobilized Rat IL-4 matrix.

Batch dependent

None

Room Temp

IL-4 antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

Il4

Interleukin 4

Rattus norvegicustus norvegicus

Il4e12, Il-4, Interleukin-4, B-cell IGG differentiation factor, IL-4

ELISA, WB

124339

Lyophilized