IL-6 Antilichaam [1,2-2B11-2G10]

IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. In addition, IL-6 appears to interact with IL2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.

3569

P05231

P05231

Human

The monoclonal antibody was produced in BALB/c x C57BL/6 F1 mice using recombinant hIL-6 as the immunizing antigen.

1.2-2B11-2G10

Unconjugated

Primary Antibodies

Immunology, Chemokines & Cytokines, Neuroscience

Batch dependent

None

Room Temp

IL-6 lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20˚ C. Reconstitute in sterile water to a concentration of 0.1 - 1.0 mg/mL. The antibody is stable for at least six weeks at 2-4˚ C when reconstituted.

IL6

Interleukin 6 (interferon, beta 2)

Homo sapiens

Interleukin 6, IFNB2, Interleukin-6, B-cell stimulatory factor 2, IL-6, HGF, HSF, BSF2

ELISA, WB

124347

Lyophilized