IL-6 Antilichaam

IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages and endothelial cells. It acts upon a variety of cells including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. In addition, IL-6 appears to interact with IL2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 is a multifunctional 24 kDa protein originally discovered in the medium of RNA stimulated fibroblastoid cells. It is upregulated by IL1, TNF, PDGF, IFN beta, TNF alpha, NGF, IL17 and downregulated by glucocorticoids IL4, TGF beta. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury, and it may prove to be as important as IL1 and TNF alpha in regulating the acute phase response. IL6 has also been implicated in regulating adipose mass.

3569

P05231

P05231

Human

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIL-6 (human Interleukin-6) .

Unconjugated

Primary Antibodies, Functional Antibodies, Antibody Pairs

Immunology, Chemokines & Cytokines, Neuroscience

Anti-hIL-6 specific antibody was purified by affinity chromatography employing immobilized hIL-6 matrix.

Batch dependent

None

Room Temp

IL-6 antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

IL6

Interleukin 6 (interferon, beta 2)

Homo sapiens

HGF, HSF, BSF2, IL-6, IFNB2, Interleukin-6, B-cell stimulatory factor 2

ELISA, WB, Neutralization Assay

124347

Lyophilized