IL-6 Recombinant eiwit

IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant rat IL-6 is a 21.7 kDa protein containing 187 amino acid residues.

24498

P20607

NP_036721.1

Recombinant Proteins

E. coli

Chemokines & Cytokines, Immunology, Neuroscience

Room Temp

The lyophilized IL-6 recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted IL-6 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing IL-6 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Interleukin 6

Rattus norvegicus

ILg6, Ifnb2, Il-6, Interleukin-6, IL-6

Rat

7549769

Lyophilized